abstract：:Progesterone, through its nuclear receptors (PR), regulates the development and growth of breast cancers. PR also serve as markers of hormone dependence and prognosis in patients with this disease, and functional PR are required to mediate the antiproliferative effects of progestin therapies. We find that normal and m...

journal_title：Breast cancer research and treatment

authors： Richer JK,Lange CA,Wierman AM,Brooks KM,Tung L,Takimoto GS,Horwitz KB

更新日期：1998-04-01 00:00:00

abstract：:Many genetic abnormalities disclosed even in somatic cells like peripheral blood lymphocytes may mark footprint(s) of malignancy(ies). The present cytogenetic study on peripheral blood lymphocytes of sporadic breast cancer patients (n = 20) and their first degree relatives (n = 39) reports abnormalities of chromosomes...

journal_title：Breast cancer research and treatment

authors： Trivedi AH,Roy SK,Bhachech SH,Patel RK,Dalal AA,Bhatavdekar JM,Patel DD

更新日期：1998-03-01 00:00:00

abstract：:The population-based Ontario Breast Screening Program (OBSP) provides two-yearly screening by both nurse examiner clinical breast examination (CBE) and two-view mammography to women aged 50 to 69. CBE alone accounts for about 5% of cancer detection. The purpose of this study was to determine whether CBE information af...

journal_title：Breast cancer research and treatment

authors： Knight JA,Libstug AR,Moravan V,Boyd NF

更新日期：1998-03-01 00:00:00

abstract：:Experimental evidence suggests an important role of the type I IGF receptor (IGF-IR) in breast cancer development. Breast tumors and breast cancer cell lines express the IGF-IR. IGF-IR levels are higher in cancer cells than in normal breast tissue or in benign mammary tumors. The ligands of the IGF-IR are potent mitog...

journal_title：Breast cancer research and treatment

authors： Surmacz E,Guvakova MA,Nolan MK,Nicosia RF,Sciacca L

更新日期：1998-02-01 00:00:00

abstract：:Mitogenic and growth inhibitory signals influence the activity of a family of cyclin dependent kinases (cdks). p27 is an important cdk inhibitor, acting in G1 to inhibit cyclin-cdks. As negative growth regulators, the cdk inhibitors may function as tumor suppressors. While the p16 gene plays a tumor suppressor role in...

journal_title：Breast cancer research and treatment

authors： Cariou S,Catzavelos C,Slingerland JM

更新日期：1998-01-01 00:00:00

abstract：:Growth, progression, and metastasis of breast cancer, as well as of most of the other tumors, are angiogenesis-dependent processes. Several pro-angiogenic growth factors and endogenous inhibitors of angiogenesis have been identified and sequenced, and experimental studies suggest that angiogenic activity of a tumor ma...

journal_title：Breast cancer research and treatment

authors： Locopo N,Fanelli M,Gasparini G

更新日期：1998-01-01 00:00:00

abstract：:The widespread use of mammography has resulted in the detection of an increasing number of small invasive breast cancers, i.e. those that are 1cm and smaller. Patients with these small cancers generally have a low incidence of axillary lymph node metastases, and this has led some to question the routine use of axillar...

journal_title：Breast cancer research and treatment

authors： Chen YY,Schnitt SJ

更新日期：1998-01-01 00:00:00

abstract：:Previously we have shown that exercising rats prior to administration of 50 mg NMU/kg (high dose) significantly decreased tumor multiplicity, but not incidence or latency. We hypothesized that the dose of NMU saturated the system such that the exercise intervention was overshadowed. Therefore, the purpose of this inve...

journal_title：Breast cancer research and treatment

authors： Whittal-Strange KS,Chadan S,Parkhouse WS

更新日期：1998-01-01 00:00:00

abstract：:Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer. Both in vitro and in vivo studies have shown that the combined administration of these two microtubule-targeting agents is feasible and worthwhile. Based on the promising preclinical data, patients with metastatic breast cance...

journal_title：Breast cancer research and treatment

authors： Tortoriello A,Facchini G,Caponigro F,Santangelo M,Benassai G,Persico G,Citarella A,Carola M,Marzano N,Iaffaioli RV

更新日期：1998-01-01 00:00:00

abstract：:Inheritance is believed to play a major role in 5-10% of breast cancer. The breast cancer susceptibility genes BRCA1 and BRCA2 are estimated to account for more than half of these cases. Recent studies have suggested that breast cancers associated with BRCA1 germline mutations are of higher grade than sporadic cases. ...

journal_title：Breast cancer research and treatment

authors： Agnarsson BA,Jonasson JG,Björnsdottir IB,Barkardottir RB,Egilsson V,Sigurdsson H

更新日期：1998-01-01 00:00:00

abstract：:The possible role of personality patterns and psychosocial factors in breast cancer has been studied extensively, through both human and animal experiments. The data are conflicting, and the conclusions controversial. This review will serve two purposes. First, we present evidence that behavioral patterns most commonl...

journal_title：Breast cancer research and treatment

authors： Hilakivi-Clarke L

更新日期：1997-11-01 00:00:00

abstract：:Considerable effort has been placed into the identification of new antineoplastic agents to treat breast cancer and other malignant diseases. The basic approaches, in terms of model selection, endpoints, and data analysis, have changed in the previous few decades. This article deals with many of the issues associated ...

journal_title：Breast cancer research and treatment

authors： Clarke R

更新日期：1997-11-01 00:00:00

abstract：:Breast cancer is one of the most common cancers in women. The laboratory rat treated with strong carcinogen is the most commonly used animal model for study of breast cancer. Transgenic mouse lines with homologues of human breast cancer oncogenes have been developed. The transgenic mouse line TG.NK with c-neu, the hum...

journal_title：Breast cancer research and treatment

authors： Rao GN,Ney E,Herbert RA

更新日期：1997-09-01 00:00:00

abstract：:Results from several randomised mammography screening trials have shown that it is possible to reduce mortality in breast cancer by mammographic screening at least for women above 50 years of age. The purpose of this article is to present data on mortality in breast cancer in study and control groups of the Stockholm ...

journal_title：Breast cancer research and treatment

authors： Frisell J,Lidbrink E,Hellström L,Rutqvist LE

更新日期：1997-09-01 00:00:00

abstract：:Transforming Growth Factor-beta (TGF beta) is the most potent known inhibitor of the progression of normal mammary epithelial cells through the cell cycle. During the early stages of breast cancer development, the transformed epithelial cells appear to still be sensitive to TGF beta-mediated growth arrest, and TGF bet...

journal_title：Breast cancer research and treatment

authors： Reiss M,Barcellos-Hoff MH

更新日期：1997-08-01 00:00:00

abstract：:We concluded a randomized crossover trial comparing tamoxifen 40 mg daily with ovarian ablation for treatment of metastatic breast cancer in premenopausal women. Objective responses (complete response (CR) plus partial response (PR)) were observed in 5/20 patients treated initially with tamoxifen and in 3/19 patients ...

journal_title：Breast cancer research and treatment

authors： Sawka CA,Pritchard KI,Shelley W,DeBoer G,Paterson AH,Meakin JW,Sutherland DJ

更新日期：1997-07-01 00:00:00

abstract：:The maintenance of hematopoietic progenitor cells as assayed in the mixed colony (CFU-GEMM) assay in human long-term bone marrow cultures was compared between normal allogeneic marrow transplantation donor collections and those from candidates for high-dose therapy and autologous bone marrow transplantation (ABMT). To...

journal_title：Breast cancer research and treatment

authors： Mann SL,Joshi SS,Crouse DA,Armitage JO,Kessinger A,Weisenburger DD,Vaughan WP,Sharp JG

更新日期：1997-06-01 00:00:00

abstract：:The incidence rate of breast cancer in Japan rose more than two-fold from 1959-60 to 1983-87. To assess to what extent this increase can be explained by changes in the prevalence of four major risk factors of breast cancer (i.e. age at menarche, age at first birth, age at menopause, and parity), we estimated the proba...

journal_title：Breast cancer research and treatment

authors： Nagata C,Kawakami N,Shimizu H

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:The outcome of breast cancer is usually determined by multiple factors. Serum tumor necrosis factor alpha concentration has been found to be increased in the circulation of patients with malignancy. This study was designed with the aim to investigate any correlation between the serum tumor necrosis factor al...

journal_title：Breast cancer research and treatment

authors： Sheen-Chen SM,Chen WJ,Eng HL,Chou FF

更新日期：1997-05-01 00:00:00

abstract：:Two human cancer cell lines (MA 2 and MA 3) were established from pleural effusions of infiltrating ductal carcinomas of the breast. The lines were maintained in continuous monolayer culture with doubling times of 70 (MA 2) and 78 (MA 3) hr for more than two years and possessed extensively rearranged abnormal karyo-ty...

journal_title：Breast cancer research and treatment

authors： Zoli W,Roncuzzi L,Zini N,Lenzi L,Gruppioni R,Barzanti F,Sensi A,Amadori D,Gasperi-Campani A

更新日期：1997-04-01 00:00:00

abstract：:To further clarify risk factors for breast cancer in Japanese women, a self-administered questionnaire was completed by 157 cases with histologically confirmed breast cancer from 1989 to 1993 and by 369 age and residential area matched controls in Gifu, Japan. Conditional logistic regression model was used to assess t...

journal_title：Breast cancer research and treatment

authors： Hu YH,Nagata C,Shimizu H,Kaneda N,Kashiki Y

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:To examine the outcomes of endocrine naive patients treated with tamoxifen as initial endocrine therapy for metastatic breast cancer. Data were obtained from the long-term follow-up of two previously published randomized trials. PATIENTS AND METHODS:All patients received tamoxifen 20 mg po in a single daily do...

journal_title：Breast cancer research and treatment

authors： Kuss JT,Muss HB,Hoen H,Case LD

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Clearance of large molecules from the interstitial space is an important function of lymphatics and is affected by local pathologic changes. OBJECTIVE:To determine if the clearance rate of interstitially injected albumin is correlated to tumour characteristics and outcome in women with invasive breast cance...

journal_title：Breast cancer research and treatment

authors： Sterns EE,SenGupta S,Zee B

更新日期：1997-01-01 00:00:00

abstract：:We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone would result in additional clinical responses. In vitro studies reported here showed verapamil sensitization of Adriamycin resistance in 18.8% of fresh human bre...

journal_title：Breast cancer research and treatment

authors： Taylor CW,Dalton WS,Mosley K,Dorr RT,Salmon SE

更新日期：1997-01-01 00:00:00

abstract：:The polypeptide hormone prolactin (Prl), acting through its cell surface receptors, promotes growth and differentiation in normal and malignant breast cells. We demonstrate herein that two Prl-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells, respond to Prl by rapid and t...

journal_title：Breast cancer research and treatment

authors： Das R,Vonderhaar BK

更新日期：1996-01-01 00:00:00

abstract：:Tamoxifen is the widespread anti-hormonal compound used for the treatment of human breast cancer. It is admitted that its effects are mediated via estrogen receptors (ER) but the molecular basis of its activity has yet to be clearly defined. In this work, we have developed a new image cytometry procedure in order to c...

journal_title：Breast cancer research and treatment

authors： Rostagno P,Caldani C,Lahlou B

更新日期：1996-01-01 00:00:00

abstract：:In a series of 205 node-negative breast cancers (NNBC), we determined staining by the novel antibody Ki-S1, a marker of tumor cell proliferation, in order to test its association with other prognostic variables and its prognostic significance. Ki-S1 was determined in routinely formalin-fixed paraffin-embedded tumor sa...

journal_title：Breast cancer research and treatment

authors： Bevilacqua P,Verderio P,Barbareschi M,Bonoldi E,Boracchi P,Dalla Palma P,Gasparini G

更新日期：1996-01-01 00:00:00

abstract：:We have compared by RNA in situ hybridisation on serial cryo-sections the distribution of cathepsin D (cathD), stromelysin 3 (strom-3), and urokinase plasminogen activator (UPA) gene expression in different tissues of human benign and malignant mammary tumors. Cath-D expression was found to be higher in adenocarcinoma...

journal_title：Breast cancer research and treatment

authors： Escot C,Zhao Y,Puech C,Rochefort H

更新日期：1996-01-01 00:00:00

abstract：:There has been increasing interest in the role of cultural and ethnic factors in breast cancer risk perceptions and screening practices. This study examined ethnic differences in breast cancer risk perception in 112 African American and 224 white women ages 35 and older who had at least one first-degree relative diagn...

journal_title：Breast cancer research and treatment

authors： Hughes C,Lerman C,Lustbader E

更新日期：1996-01-01 00:00:00

abstract：:Prognostication of breast cancer patients, not operated at diagnosis, poses a clinically difficult problem. To use gene amplification we examined cytological samples and determined c-erb-B2 gene copy number with semi-quantitative PCR. Control experiments showed the same gene-copy number in aliquots that were either ai...

journal_title：Breast cancer research and treatment

authors： Lönn U,Lönn S,Nilsson B,Stenkvist B

更新日期：1996-01-01 00:00:00

abstract：:Progression of breast cancer from an estrogen-dependent, slowly growing tumor amenable to tamoxifen treatment to an aggressive, metastatic, estrogen-independent phenotype has been mimicked by the transfection of MCF-7 breast carcinoma cells with fibroblast growth factors 1 or 4. FGF-transfected cells are aggressively ...

journal_title：Breast cancer research and treatment

authors： McLeskey SW,Zhang L,Kharbanda S,Kurebayashi J,Lippman ME,Dickson RB,Kern FG

更新日期：1996-01-01 00:00:00

abstract：:The development of recombinant vaccines for specific immunotherapy of carcinoma represents a novel approach for the treatment of breast cancer and other tumor types. This article reviews the various parameters that should be considered in the development of recombinant vaccines. Several breast cancer associated antige...

journal_title：Breast cancer research and treatment

authors： Schlom J,Kantor J,Abrams S,Tsang KY,Panicali D,Hamilton JM

更新日期：1996-01-01 00:00:00

abstract：:In breast cancer, the survival rate strongly depends on the number of lymph nodes involved. A drug with a specific inhibitory activity on lymph node and organ metastases would therefore be a candidate for adjuvant therapy after surgery. Prostacyclin and its stable analogues have been shown to interfere with certain st...

journal_title：Breast cancer research and treatment

authors： Schneider MR,Schirner M,Lichtner RB,Graf H

更新日期：1996-01-01 00:00:00

abstract：:In this prospective study, the authors examined 50 patients with breast tumors (malignant, n = 32; benign, n = 18) to investigate the correlation between color Doppler flow mapping and histopathological findings and to evaluate the clinical significance of color Doppler mapping. Among the 32 patients with breast cance...

journal_title：Breast cancer research and treatment

authors： Lee WJ,Chu JS,Huang CS,Chang MF,Chang KJ,Chen KM

更新日期：1996-01-01 00:00:00

abstract：:From January 1992 to July 1993, 28 patients with metastatic breast cancer were entered in a phase II trial to assess the activity and toxicity of the combination of mitoxantrone, 5-fluoruracil, and leucovorin. Patients were eligible if they had progressive disease after either adjuvant (2 patients) or previous chemoth...

journal_title：Breast cancer research and treatment

authors： Colozza M,Gori S,Mosconi AM,Anastasi P,Basurto C,Ludovini V,De Angelis V,Giansanti M,Tonato M

更新日期：1996-01-01 00:00:00

abstract：:The present study consists of 1,238 women with unilateral breast cancer treated with modified radical mastectomy living in the geographic area of Haukeland Hospital. Their weight and height had been measured years before presentation of the disease. Age-adjusted Quetelet's index (weight/height2) showed that obese wome...

journal_title：Breast cancer research and treatment

authors： Maehle BO,Tretli S

更新日期：1996-01-01 00:00:00

abstract：:A new method of measuring gene copy number in small samples of DNA was used to measure amplification of the erbB-2 gene and of chromosome 20q in breast cancer. This method, termed 'differentially competitive polymerase chain reaction' (DC-PCR) combines the advantages of two other techniques for measuring amplification...

journal_title：Breast cancer research and treatment

authors： Deng G,Yu M,Chen LC,Moore D,Kurisu W,Kallioniemi A,Waldman FM,Collins C,Smith HS

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:This trial studied the disease-free survival after high-dose chemotherapy in patients in complete remission of metastatic breast cancer. PATIENTS AND METHODS:Thirty women, mean age 42.2 years (range 33-55) with metastatic breast cancer, received high-dose chemotherapy in a phase II study. Patients were elig...

journal_title：Breast cancer research and treatment

authors： de Vries EG,Rodenhuis S,Schouten HC,Hupperets PS,Dolsma WV,Lebesque JV,Blijham GH,Bontenbal M,Mulder NH

更新日期：1996-01-01 00:00:00

abstract：:The expression of amphiregulin (AR), heregulin (HRG), and cripto-1 (CR-1) mRNA transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts were expressed respectively in 58% and 25% of the carcinomas as measured by Northern blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Rev...

journal_title：Breast cancer research and treatment

authors： Normanno N,Kim N,Wen D,Smith K,Harris AL,Plowman G,Colletta G,Ciardiello F,Salomon DS

更新日期：1995-09-01 00:00:00

abstract：:Proliferation of both mouse and human breast cancer cells was inhibited by chlorpheniramine (CPA) in a dose-response manner. At the beginning of the exponential phase of growth (two days after seeding), 250 microM CPA was able to reduce cell proliferation by 75% (in Ehrlich cell cultures) and 30% (in MCF-7 cultures). ...

journal_title：Breast cancer research and treatment

authors： Medina MA,García de Veas R,Morata P,Lozano J,Sánchez-Jiménez F

更新日期：1995-08-01 00:00:00